3D Max, Photoshop, Illustrator
The angel girl and baby Jesus are 3D. 3D isn't my strong suit, but I think they came out nice.
The background is a digital photo of two pillows; one to represent ground, the other sky. I used extreme selective focus to allow everything except the piece of ground the cradle is on to blur. I took the photo into Photoshop and beat on the color until I hit something I thought would work.
The stars and text are Illustrator. I created one star, then used the scatter brush option so I could simply draw a few paths and multiple stars would appear.
The text is Nueva Std bold, with a drop shadow behind it.
The Bible verse comes from the gospel of Luke, where he relates the astounding miraculous details surrounding and including the birth of our Jesus Christ, our Lord and Savior. Luke also wrote the book of Acts, and is renowned for his historical accuracy and details.
Merry Christmas. :)